HORDB

ID: hor001098
Uniprot ID: A0A921YVE1
Protein name: FLRFamide
Gene name: NA
Organism: Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Family: FMRFamide related peptide family
Source: animal
Expression: in the middle and posterior regions of the midgut
Disease: NA
Comments: NA
Taxonomy: Manduca (genus), Sphingini (tribe), Sphinginae (subfamily), Sphingidae (family), Bombycoidea (superfamily), Obtectomera, Ditrysia, Heteroneura (parvorder), Neolepidoptera (infraorder), Glossata (suborder), Lepidoptera (order), Amphiesmenoptera (superorder), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: NA
GO CC: NA

Sequence: YAEAAGEQVPEYQALVRDYPQLLDSGMKRQDVVHSFLRF
Length: 39
Propeptide: MNVIGEHCRFALVCVVMCWLVSVVVCAPAQLCAGAAEDDPRAARFCQALNTFLELYAEAAGEQVPEYQALVRDYPQLLDSGMKRQDVVHSFLRFGRRR
Signal peptide: NA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001098_AF2.pdb

hor001098_ESM.pdb

Mass:	520607	Formula:	C203H309N55O61S
Absent amino acids:	CINTW	Common amino acids:	ALQV
pI:	4.73	Basic residues:	5
Polar residues:	7	Hydrophobic residues:	14
Hydrophobicity:	-47.18	Boman Index:	-7767
Half-Life:	2.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	2 min	Aliphatic Index	80
Instability Index:	6249.74	Extinction Coefficient cystines:	4470
Absorbance 280nm:	117.63

PubMed ID: 9359469
Title: Identification of Neuropeptides in the Midgut of Parasitized Insects: FLRFamides as Candidate Paracrines